مرکز منطقه ای اطلاع رسانی علوم و فناوری Journal of Information Systems and Telecommunication (JIST) 2322-1437 13 51 2025 11 2 Predicting Primary Biliary Cholangitis Stages Using Machine Learning with Automated Hyperparameter Optimization and Recursive Feature Elimination Predicting Primary Biliary Cholangitis Stages Using Machine Learning with Automated Hyperparameter Optimization and Recursive Feature Elimination 165 176 10.61882/jist.49352.13.51.165 en Arman Rezasoltani University of Tehran Amir Mohammad Khani دانشگاه تهران Ali Husseinzadeh Kashan Tarbiat Modares University, Shahram Agah Iran University of Medical Sciences Fatemeh Agah The University of Adelaide 2025 1 30 <p class="Sammary" style="page-break-after: auto;">This research used modern machine learning ways to predict the stages of primary biliary cholangitis using data from the Mayo Clinic trial. The research aims to obtain high prediction accuracy while representing balanced evaluation metrics. Important techniques include automated hyperparameters optimization with Optuna and Recursive Feature Elimination to improve model performance. Pre-processing included handling missing values, encoding of categorical features, and addressing class imbalances using SMOTE. A total of twelve machine learning algorithms are evaluated with ensemble-based models such as CatBoost and Extra Trees producing much better results. Evaluation metrics take into account all model predictions, including accuracy, precision, recall, F1 score, and ROC-AUC for performing balanced and interpretative evaluations of performances critical for imbalanced datasets. This endeavor includes clinical and laboratory information illustrating the prospect of machine learning in advancing therapeutic diagnosis, emphasizing the rigor and robustness in evaluation laid groundwork for future research to encompass even more generalizable and robust diagnostic tools.</p> http://jist.ir/en/Article/Download/49352